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Science has a lot going wrong with it. Here are some I can list: P-values, the h-index (article discusses), the funding crunches and (US specific) the cyclic nature of NIH funding, the massively skewed incentives of publish or perish, the entire idea of trying to assign value to discoveries (article discusses), the 2-body problem of family life and science (at least the Germans expect you to have no life and are clear on that), the work-life non-balance, the relatively very poor pay, the hyper-competition and sabotage (in some fields, labs, or universities), the total ignorance of doctors/politicians that take your work and apply it in appalling ways, the entire racket of scientific publishing, etc. As always, we should point out to newcomers to this discussion of one of the most read scientific paper EVER by John P. Ioannidis "Why Most Published Research Findings Are False" [0]. If you don't have access and don't want to use Sci-Hub or ICanHazPDF, here is a youtube of John discussing his work [1]. You can use the google to really jump into a rabbit hole here. Essentially, flip a coin, heads the paper is right, tails the paper is wrong, it really is that bad these days. Ok, so lets just scrap the whole thing then, right? Here is why not: link link link link this video (a good showing of why science is right and helps folks) link So, yeah, science is a mess right now. But if we scientists don't step up and make it not a mess, those scummy money-grubbing scammer dirtbags