Rhonda Patrick gives an IHMC talk on how genetic variation affects micronutrient absorption and metabolism, and how diet changes gene expression. It also covers epigenetics, including heritable changes, and stress tolerance.
Why Hacker News points people here: Cited as a reference in threads on telomeres, lifespan extension and longevity research funding, mainly for the nutrigenomics and epigenetics material.
“using micronutrients such as Vitamin D, magnesium as described here”
Explains micronutrients like vitamin D and magnesium affecting telomerase and FOXO3.
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It's also interesting to note how we can affect the length of our Telomeres via Telomerase and FOXO3 genes using micronutrients such as Vitamin D, magnesium as described here this video This is being worked on by companies in the epigenetics and human life extension areas: link (Google and Genentech) link (Berkeley Lab) link (Aubrey De Grey & Peter Theil)
Cites itmeeper16May 2015
“Epigentics and extending human lifespan”
On epigenetics and extending human lifespan.
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Were almost near the starting line with research and companies like Human Longevity, CalicoLabs(Google,Genentech), GenoPharmix, Buck Institute, SENS Foundation and this: Cynthia Kenyon: Experiments that hint of longer link Epigentics and extending human lifespan: this video
Cites itKasianFranksJan 2016
“Nutrigenomics, Epigenetics, and Stress Tolerance”
Part of a chain of sources linking nutrigenomics and lifespan.
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AI applied to understanding the hidden relationships linking epigentics and extending human lifespan via algorithmically engineered diet, nutrition and longevity genomics: The precedent: Laura Deming: Making a business out of fighting the ills of aging link Cynthia Kenyon: Experiments that hint of longer lives (Cynthia now works at Google's Calico Labs) link Now connect this: Nutrigenomics, Epigenetics, and Stress Tolerance this video Now combine with: What is Epigenetics? with Nessa Carey The last 10mins are very important, in particular minute 35:06 link Statistical modeling of biomedical corpora: mining the Caenorhabditis Genetic Center Bibliography for genes related to life span - Blei DM1, Franks K, Jordan MI, Mian IS. - link Combining the worlds variants of pattern recogition, machine learning and AI with data associated to epigentic and standard genomic experiments and information, we should be able to discover hidden relationships that will enable advancement in extending human lifespan. Revenue is something we'll need to focus on and that may come in the form of consumer applications that algorithmically engineer their epigenome with data from companies like 23andMe, Navigenics, Ubiome etc. connected to Nutrigenomics including plant compounds, phytochemicals mapped all the way to the consumer through foods connected to apps connected shopping and recipe experiences. Finally connect to CRISPR and Gene Therapy Jennifer Doudna, inventor of CRISPR: We can now edit o
