A short FoundMyFitness explainer on the trade-off between growth hormone/IGF-1 and longevity. Higher IGF-1 helps muscle and cognition, while lower levels are linked to longer lifespan and stress resistance.
Why Hacker News points people here: Linked in discussions of diet, aging and cancer as a quick summary of how IGF-1 and mTOR growth signaling cut against longevity.
“video is replete with examples of the effects of low IGF-1/GH or high IGF-1/GH both in animal models and humans.”HN comment, 2014
“video is replete with examples of the effects of low IGF-1/GH or high IGF-1/GH both in animal models and humans.”
Effects of low versus high IGF-1 in animals and humans
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Speaking to your question about "what the long term effects of these drugs are": My wife put together a together a pretty interesting video about the "faustian bargain" which is IGF-1 (used as a proxy measure for growth hormone)... video is replete with examples of the effects of low IGF-1/GH or high IGF-1/GH both in animal models and humans. One of the more interesting points in the video is the fact that people with polymorphisms that make their IGF-1 receptor experience some slight loss of function actually live longer (in general). this video The video also links to an article which has a bibliography if you're interested.
Cites itfemiagbabiakaApr 2021
“there's a lot of research showing that high levels of IGF-1 associated with diets high in red meat are not good for longevity”
High IGF-1 from red meat diets associated with worse longevity
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1. Bigger groups === more and better data. I didn't know anyone growing up who was interested in ketogenic or carnivorous diets, now it's much more common. 2. Huge difference between the diet of a westerner following carnivore and traditional tribal carnivorous diets 3. The Inuits weren't particularly healthy, I'm not sure why their diet matters: link 4. And most importantly, there's a lot of research showing that high levels of IGF-1 associated with diets high in red meat are not good for longevity: this video
Cites itloudtieblahblahMar 2022
“mtor/igf-1 stimulates growth. All growth. This is great for youth. Not so much for aging.”
IGF-1 stimulates growth, good for youth, bad for aging
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linklink Its pretty well know mtor/igf-1 stimulates growth. All growth. This is great for youth. Not so much for aging. this video
