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Well, if proximity detonation is an issue, there's always weapons like CIWS [1] and C-RAM [2]. I imagine there could easily be some kind of adaption made for specialized ammo. Instead of typical bullets, use some kind of very low grade concussive. The explosive wouldn't necessarily need to be an explosive , but merely just something to disrupt the air around one or two blades of the drone to force it into an unrecoverable spin. Similar to small grade concussives, I've heard some interesting defense systems use a projectile that has a kind of "mini parachute" to overwhelm target acquisition systems. I can't recall what it was in relation to. Chaff, maybe? The point is, if you could get enough small objects floating in the area, you could make it much harder for an enemy drone to maneuver within a specific area. Honestly, I think the soon-to-be hurdle would be around implementing a good jamming system against automated defenses, which would probably lead to inventing some sort of miniaturized version of current fighter planes, but built in such a way that doesn't need to account for things like G tolerance for pilots. [1] this video [2] link