Talks to Watch

Jack Szostak (Harvard/HHMI) Part 1: The Origin of Cellular Life on Earth

379K views · Jan 11, 2012 · 54:41 · 6 HN recommenders · 7 mentions · discussed 2016–2021

Jack Szostak's lecture covers how cellular life could have arisen from chemistry on the early Earth, starting from the odds of life elsewhere in the galaxy. It is part of a series on protocells and the RNA world.

Why Hacker News points people here: Recommended as a clear, authoritative lecture series on plausible origin-of-life theories.

“Jack Szostak does a pretty good job of outlining how life might have arisen.”HN comment, 2019

What Hacker News said 7

Strongly recommendslawpoopJul 2016

“Jack Szostak has done an excellent series of short videos on the theory”

Short video series on RNA world theory and supporting experiments

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I personally am a fan of the RNA world hypothesis: link RNA can act as both a store of information, and as an enzyme catalyzing reactions. In this theory, certain sequences of RNA would be the original self-replicating molecules. Over time, variations in their replication would give rise to other enzymes for specialized reactions, and DNA as a pure-data store. Jack Szostak has done an excellent series of short videos on the theory, and he and his students have done a surprising amount of experiments to support the theory. this video

in “Luca, the Ancestor of All Living Things” · view on HN
Recommends21Jul 2017

“I found this 3 part talk which discusses how the simplest possible life form might have looked like.”

Three-part talk on what the simplest possible life form might look like

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Recently I got interested in the origin of life. I found this 3 part talk which discusses how the simplest possible life form might have looked like. My feeling after watching this is that we are slowly getting there (which will also mean jump starting in a dish a self replicating thing from inorganic matter). this video link link

Recommendschr1Feb 2019

“This series of presentation by Jack Szostak is rather interesting”

Presentation series on assembling life from simple molecules

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There are also people trying to assemble life from simpler molecules that are commonly formed in non-organic processes. This series of presentation by Jack Szostak is rather interesting this video

in “‘Minimal’ cell raises stakes in race to harness synthetic life (2016)” · view on HN
RecommendstrevynMay 2019

“Jack Szostak does a pretty good job of outlining how life might have arisen.”

Clear outline of how life might have arisen

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Jack Szostak does a pretty good job of outlining how life might have arisen. It’s less mysterious than it intuitively might seem: this video link

in “New physics needed to probe the origins of life” · view on HN
RecommendsmartythemaniakFeb 2020

“Here's a starter pack”

Origin of life lecture in a starter pack of resources

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I found it cute and quite meaningful. If you spend a good deal of time on Cellular Automata, Dissipative Structures and genetics these things really start to jump out at you. Here's a starter pack: Cellular Automata and Computation: link Origin of Life: this video Dissipative Structures: link

in “Cellular Automata in the Browser” · view on HN
RecommendslovecgJan 2021

“Fun lecture series”

Lecture series on plausible theories of life's origin

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There are some plausible theories, like RNA randomly crystallizing on a suitable surface. Sooner or later a self-copying one just happened to crystallize by chance, and there was no going back. Fun lecture series: this video

in “Time-lapse of a single cell transforming into a salamander (2019)” · view on HN
Cites itmartythemaniakApr 2020

Cited alongside dissipative structures as related reading

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Look into "dissipative structures", which are indeed closely linked to thermodynamics. In short, energy gradients (ie, on hydrothermal vents) can cause matter to organize itself into structures that more efficiently dissipate this energy. You can see how the creation of this structure would in turn enable the creation of a new kind of structure that lives on top of that. link this video

in “What's a virus, anyway? The bare-bones basics” · view on HN